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Varox 2.5 mg is prescribed to prevent atherothrombotic events in adults following Acute Coronary Syndrome (ACS) who have elevated cardiac biomarkers such as Troponin or CK-MB. It is used alongside Aspirin alone, or Aspirin with Clopidogrel or Ticlopidine.
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ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Rivaroxaban is a selective, direct Factor Xa inhibitor. By inhibiting Factor Xa, it blocks both the intrinsic and extrinsic pathways of the coagulation cascade, thereby preventing thrombin generation. It does not inhibit thrombin (activated Factor II) and has no demonstrated effect on platelets.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects
Most common: bleeding risk (including fatal bleeding), spinal/epidural hematoma, and increased risk of stroke upon discontinuation in nonvalvular atrial fibrillation.
✔️ Dosage & Administration
For ACS: 2.5 mg twice daily with 75–100 mg Aspirin daily, with or without 75 mg Clopidogrel or standard-dose Ticlopidine.
Nonvalvular Atrial Fibrillation:
CrCl > 50 mL/min: 20 mg once daily with evening meal.
CrCl 15–50 mL/min: 15 mg once daily with evening meal.
DVT & PE Treatment: 15 mg twice daily with food for 21 days, then 20 mg once daily with food.
Prevention of DVT/PE Recurrence: 20 mg once daily with food.
Post-hip replacement prophylaxis: 10 mg once daily for 35 days.
Post-knee replacement prophylaxis: 10 mg once daily for 12 days.
May be taken with or without food (except where food intake is specified).
✔️ Drug Interactions
Avoid with combined P-gp and CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin, erythromycin, fluconazole, diltiazem, verapamil, dronedarone) due to increased exposure and bleeding risk.
Avoid with P-gp and strong CYP3A4 inducers (rifampicin, phenytoin, carbamazepine) due to reduced efficacy.
Caution with antiplatelet agents, heparin, fibrinolytics, and NSAIDs, as these increase bleeding risk.
✔️ Contraindications
Hypersensitivity to Rivaroxaban or excipients.
Active pathological bleeding.
✔️ Pregnancy & Lactation
Category C: No adequate human studies; dosing not established for pregnancy.
Unknown if excreted in breast milk; safety not established in breastfeeding.
✔️ Precautions & Warnings
- Stopping therapy early without alternative anticoagulation increases thrombotic risk.
- Bleeding risk is higher in patients with bleeding disorders, uncontrolled hypertension, GI diseases (IBD, oesophagitis, gastritis, GERD), vascular retinopathy, bronchiectasis, or a history of pulmonary bleeding.
- Monitor for neurological symptoms if neuraxial anesthesia or spinal puncture is performed (risk of spinal/epidural hematoma).
- Not recommended in PE with hemodynamic instability or when thrombolysis/pulmonary embolectomy is planned.
✔️ Storage:
Store below 30 °C, in a cool, dry place away from light and out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
